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<Journal>
<PublisherName>isfcppharmaspire</PublisherName>
<JournalTitle>Pharmaspire</JournalTitle>
<PISSN>C</PISSN>
<EISSN>o</EISSN>
<Volume-Issue>Volume 16, Issue 02, 2024</Volume-Issue>
<PartNumber/>
<IssueTopic>Multidisciplinary</IssueTopic>
<IssueLanguage>English</IssueLanguage>
<Season>April - June</Season>
<SpecialIssue>N</SpecialIssue>
<SupplementaryIssue>N</SupplementaryIssue>
<IssueOA>Y</IssueOA>
<PubDate>
<Year>2025</Year>
<Month>10</Month>
<Day>9</Day>
</PubDate>
<ArticleType>Pharmacy Practice</ArticleType>
<ArticleTitle>Evaluating the impact of iron deficiency anemia on quality of life using the FACT-Anemia scale in a tertiary care hospital</ArticleTitle>
<SubTitle/>
<ArticleLanguage>English</ArticleLanguage>
<ArticleOA>Y</ArticleOA>
<FirstPage>45</FirstPage>
<LastPage>53</LastPage>
<AuthorList>
<Author>
<FirstName>Gulam</FirstName>
<LastName>Varish1</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>N</CorrespondingAuthor>
<ORCID/>
<FirstName>Kousik</FirstName>
<LastName>Maparu2</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
<FirstName>Rohit3*</FirstName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
</Author>
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<DOI>https://doi.org/10.56933/Pharmaspire.2024.16201</DOI>
<Abstract>Background: Iron deficiency anemia (IDA) reduces oxygen delivery, causing fatigue and a reduced quality of life. Despite its impact on daily functioning is often underestimated. The assessment of QoL in IDA is effective using the FACT-Anemia scale.
Objectives: The research focused on assessing health-related QoL in IDA patients using the FACT-Anemia questionnaire at a tertiary care hospital.
Methodology: A cross-sectional study (January through April 2025) with a convenience sample of 140 cases with IDA sought out patients enrolled with major comorbidities or pregnant patients. All patients completed the FACT-An (FACT-G severe fatigue subscale __ampersandsign anemia subscale). Clinical and Hemoglobin data were recorded. To analyze all predictors of FACT-An scores, Spearman__ampersandsign#39;s correlation, Kruskal-Wallis tests, and standard multivariable regression were used.
Results: Among 140 participants (mean age group 19-28 years, 50.7% male), the severity of anemia significantly impacted QoL scores derived through the FACT-Anemia scale. A statistically significant week was observed, but negative correlations were found between hemoglobin and QoL scores (r? = -0.217, p = 0.010). The analysis using the Kruskal-Wallis test found a clear link between disease severity and overall QoL (p =</Abstract>
<AbstractLanguage>English</AbstractLanguage>
<Keywords>Iron deficiency anemia, Quality of life, FACT-Anemia scale, Fatigue, Hemoglobin Levels</Keywords>
<URLs>
<Abstract>https://www.isfcppharmaspire.com/ubijournal-v1copy/journals/abstract.php?article_id=15984&title=Evaluating the impact of iron deficiency anemia on quality of life using the FACT-Anemia scale in a tertiary care hospital</Abstract>
</URLs>
<References>
<ReferencesarticleTitle>References</ReferencesarticleTitle>
<ReferencesfirstPage>16</ReferencesfirstPage>
<ReferenceslastPage>19</ReferenceslastPage>
<References>References:
1.Gilbert A, Sebag-Montefiore D, Davidson S, Velikova G. Use of patient-reported outcomes to measure symptoms and health-related quality of life in the clinic. Gynecologic oncology. 2015 Mar 1;136(3):429-39.
2.Natalucci V, Virgili E, Calcagnoli F, Valli G, Agostini D, Zeppa SD, Barbieri E, Emili R. Cancer-related anemia: an integrated multitarget approach and lifestyle interventions. Nutrients. 2021 Feb 1;13(2):482.
3.Hempel EV, Bollard ER. The evidence-based evaluation of iron deficiency anemia. Medical Clinics. 2016 Sep 1;100(5):1065-75.
4.Safiri S, Kolahi AA, Noori M, Nejadghaderi SA, Karamzad N, Bragazzi NL, Sullman MJ, Abdollahi M, Collins GS, Kaufman JS, Grieger JA. Burden of anemia and its underlying causes in 204 countries and territories, 1990–2019: results from the Global Burden of Disease Study 2019. Journal of hematology and; oncology. 2021 Dec;14:1-6.
5.Stauder R, Valent P, Theurl I. Anemia at older age: etiologies, clinical implications, and management. Blood, The Journal of the American Society of Hematology. 2018 Feb 1;131(5):505-14.
6.Muthanna FM, Hassan BA, Karuppannan M, Mohammed AH. Evaluation of the impact of anaemia on quality of life among breast cancer patients undergoing chemotherapy in Malaysia. Journal of Pharmaceutical Health Services Research. 2021 Jun 1;12(2):310-2.
7.Raza S, Wei J, Ashad Abid S, Azhar G. Are Blood Transfusions Useful for Non-Specific Symptoms of Anemia in the Elderly?. The Open Medicine Journal. 2014 Jul 11;1(1).
8.Bhandari S, Parfrey P, White C, Anker SD, Farrington K, Ford I, Kalra PA, McMurray JJ, Robertson M, Tomson CR, Wheeler DC. Predictors of quality of life in patients within the first year of commencing haemodialysis based on baseline data from the PIVOTAL trial and associations with the study outcomes. Journal of Nephrology. 2023 Jul;36(6):1651-62.
9.Dahl NV, Moore A, Jiang J, Strauss WE. Sustained Improvements in Anemia and Fatigue of AUB after a Single Course of Ferumoxytol: 6-Month Follow-up [20J]. Obstetrics and; Gynecology. 2019 May 1;133:112S-3S.
10.Safiri S, Carson-Chahhoud K, Noori M, Nejadghaderi SA, Sullman MJ, Heris JA, Ansarin K, Mansournia MA, Collins GS, Kolahi AA, Kaufman JS. Burden of chronic obstructive pulmonary disease and its attributable risk factors in 204 countries and territories, 1990-2019: results from the Global Burden of Disease Study 2019. Bmj. 2022 Jul 27;378.
11.Kumar SB, Arnipalli SR, Mehta P, Carrau S, Ziouzenkova O. Iron deficiency anemia: efficacy and limitations of nutritional and comprehensive mitigation strategies. Nutrients. 2022 Jul 20;14(14):2976.
12.Bathla S, Arora S. Prevalence and approaches to manage iron deficiency anemia (IDA). Critical Reviews in Food Science and Nutrition. 2022 Nov 14;62(32):8815-28.
13.Saboor M, Zehra A, Hamali HA, Mobarki AA. Revisiting Iron Metabolism, Iron Homeostasis, and Iron Deficiency Anemia. Clinical Laboratory. 2021 May 1(3).
14.Pasricha SR, Tye-Din J, Muckenthaler MU, Swinkels DW. Iron deficiency. The Lancet. 2021 Jan 16;397(10270):233-48.
15.English E, Idris I, Smith G, Dhatariya K, Kilpatrick ES, John WG. The effect of anaemia and abnormalities of erythrocyte indices on HbA1c analysis: a systematic review. Diabetologia. 2015 Jul;58:1409-21.
16.Wagh D, Kanase S, Balid A, Fulari S, Bhosale A, Wadkar S, Gurud T, Narawade T, Walekar S. A Brief Review on Anemia. Int. J. Sci. R. Tech. 2024;1(12).
17.Chaparro CM, Suchdev PS. Anemia epidemiology, pathophysiology, and etiology in low?and middle?income countries. Annals of the New York Academy of Sciences. 2019 Aug;1450(1):15-31.
18.Ciebiera M, Esfandyari S, Siblini H, Prince L, Elkafas H, Wojty?a C, Al-Hendy A, Ali M. Nutrition in gynecological diseases: current perspectives. Nutrients. 2021 Apr 2;13(4):1178.
19.Bhadra P, Deb A. A review of nutritional anemia. Indian Journal of Natural Sciences. 2020 Jun;10(59):18466-74.
20.Khajuria A, Raju M, Verma MK. Iron Deficiency Anemia: An Updated Review. International Journal. 2022 May;5(3):757.
21.Mo A, Poynton M, Wood E, Shortt J, Brunskill SJ, Doree C, Sandercock J, Saadah N, Luk E, Stanworth SJ, McQuilten Z. Do anemia treatments improve quality of life and physical function in patients with myelodysplastic syndromes (MDS)? A systematic review. Blood Reviews. 2023 Sep 1;61:101114.
22.Busti F, Marchi G, Ugolini S, Castagna A, Girelli D. Anemia and iron deficiency in cancer patients: role of iron replacement therapy. Pharmaceuticals. 2018 Sep 30;11(4):94.
23.Acaster S, Dickerhoof R, DeBusk K, Bernard K, Strauss W, Allen LF. Qualitative and quantitative validation of the FACIT-fatigue scale in iron deficiency anemia. Health and quality of life outcomes. 2015 Dec;13:1-0.
24.Stute P, Akpan IJ, Breymann C, Murji A, Oand;#39;Brien SH, Powers JM, Munro MG. Effect of Ferric Derisomaltose on Fatigue in Iron Deficiency Anemia Associated With Abnormal Uterine Bleeding. American Journal of
25.Gluszak C, de Vries-Brilland M, Seegers V, Baroin C, Kieffer H, Delva R, Cornuault-Foubert D. Impact of iron-deficiency management on quality of life in patients with cancer: a prospective cohort study (CAMARA study). The Oncologist. 2022 Apr 1;27(4):328-33.
26.Portugal-Nunes C, Castanho TC, Amorim L, Moreira PS, Mariz J, Marques F, Sousa N, Santos NC, Palha JA. Iron status is associated with mood, cognition, and functional ability in older adults: a cross-sectional study. Nutrients. 2020 Nov 23;12(11):3594.
27.Kulkarni A, Khade M, Arun S, Badami P, Kumar GR, Dattaroy T, Soni B, Dasgupta S. An overview on mechanism, cause, prevention, and multi-national policy level interventions of dietary iron deficiency. Critical Reviews in Food Science and Nutrition. 2022 Jun 29;62(18):4893-907.
28.Cella D, Lai JS, Chang CH, Peterman A, Slavin M. Fatigue in cancer patients compared with fatigue in the general United States population. Cancer. 2002 Jan 15;94(2):528-38.
29.Jankowska EA, Rozentryt P, Witkowska A, Nowak J, Hartmann O, Ponikowska B, Borodulin-Nadzieja L, Banasiak W, Polonski L, Filippatos G, McMurray JJ. Iron deficiency: an ominous sign in patients with systolic chronic heart failure. European Heart Journal. 2010 Aug 1;31(15):1872-80.
30.Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood. 2004 Oct 15;104(8):2263-8.
31.Knight K, Wade S, Balducci L. Prevalence and outcomes of anemia in cancer: a systematic review of the literature. The American journal of medicine. 2004 Apr 5;116(7):11-26.</References>
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